It really is tricky to determine what constitutes a normal harmful or lethal dose. On the other hand, the lethal oral dose of codeine in an adult is documented being during the range of 0.
Promethazine administered to your Expecting lady inside of two weeks of shipping could inhibit platelet aggregation while in the newborn.
To reduce your danger, your medical doctor ought to have you take the smallest dose that actually works, and just take it with the shortest possible time. See also The best way to Use portion For more info about addiction.
Symptoms and indications of overdosage with promethazine HCl range from mild depression from the central anxious method and cardiovascular program to profound hypotension, respiratory depression, unconsciousness, and unexpected Loss of life.
Children may be much more delicate towards the Unwanted side effects of this drug, Primarily slowed breathing and uncontrolled movements (see also Warning portion). Young children could also knowledge excitability instead of drowsiness.
To scale back the risk of dizziness and lightheadedness, stand up slowly when soaring from the sitting or lying position.
Codeine Codeine can be an opioid agonist comparatively selective for your mu-opioid receptor, but having a Significantly weaker affinity than morphine. The analgesic and antitussive Homes of codeine have already been speculated to come from its conversion to morphine.
Promethazine Carcinogenicity scientific tests ended up conducted with promethazine hydrochloride. Two-year experiments in F344/N rats and B6C3F1 mice ended up done to assess the carcinogenic probable of promethazine hydrochloride. No proof of tumorigenicity was noticed in male and feminine rats at promethazine hydrochloride oral doses as much as 33 mg/kg/day for five times/week (about reminiscent of ten situations the MRHD over a mg/m2 basis).
This could certainly transpire Even when you just take Promethazine Hydrochloride and Codeine Phosphate Oral Option precisely as prescribed by your Health care provider. Your chance of addiction, abuse, and misuse is amplified in case you or even a loved one features a history of drug or Liquor abuse or habit, or psychological health issues.
A household teaspoon is just not an exact measuring system and could lead to overdosage, particularly when fifty percent a teaspoon is to be calculated. It is strongly advisable that an precise measuring device be utilized. A pharmacist can offer an correct unit and can provide instructions for measuring the right dose.
This medication may perhaps consist of sugar Promethazine codeine syrup and/or Liquor. Warning is recommended When you have diabetic issues, alcohol dependence, or liver illness. Check with your medical professional or pharmacist about working with this merchandise safely.
Explain to your care group In the event your ache doesn't go away, if it will get worse, or if you have new or a different sort of discomfort.
Carefully evaluate the dose employing a Unique measuring machine/spoon. Do not utilize a residence spoon because you might not get the proper dose.
Codeine and promethazine, two of the active components in Promethazine HCl and Codeine Phosphate Oral Resolution, might make marked drowsiness and impair the mental and/or physical talents essential with the functionality of probably harmful responsibilities for example driving a vehicle or working machinery. Suggest patients in order to avoid participating in hazardous duties requiring mental alertness and motor coordination following ingestion of Promethazine HCl and Codeine Phosphate Oral Resolution.